Modulation of Mammary Gland Development in Prepubertal Male Rats Exposed to Genistein and Methoxychlor
نویسندگان
چکیده
منابع مشابه
Altered mammary gland development in male rats exposed to genistein and methoxychlor.
Genistein (GE) is a prevalent phytoestrogen whose presence in human and animal foods may affect biological actions of synthetic endocrine active compounds. We have previously reported that in utero and lactational exposure to high doses of GE or the endocrine active pesticide methoxychlor (MXC) caused mammary epithelial proliferation in 21-day-old male rats. Combined exposure to GE and MXC resu...
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15 صفحه اولEffects of genistein on male sprague dawley rats reproductive development
Genistein (Gen), is commonly consumed phytoestrogen among Asian and known to exert weak estrogenic effects. To account for potential reproductive effects in male rats, Control, Gen1, Gen10, Gen100 mg/kg body weight and Estradiol were administered to gestational day 10 (GD10) female Sprague Dawley for 5 weeks. At postnatal day, P50, the rats were sacrificed. Blood was taken and reproductive tiss...
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The aim of this study was to determine the effects of restricted feeding before puberty on growth performance and mammary gland development in replacement ewe lambs. At weaning, 72 Dorset ewe lambs were assigned to one of the three diets: an ad libitum control diet with medium-quality forage (MQF; diet A-MQF); a restricted diet with the same forage as A, but less feed concentrate (diet R-MQF); ...
متن کاملCombined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague-Dawley rats: genistein and methoxychlor.
Humans and wildlife are frequently exposed to mixtures of endocrine active-compounds (EAC). The objective of the present study was to investigate the potential of the phytoestrogen genistein to influence the reproductive developmental toxicity of the endocrine-active pesticide methoxychlor. Three levels of genistein (0, 300, or 800 ppm) and two levels of methoxychlor (0 or 800 ppm) were used in...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2002
ISSN: 1096-0929
DOI: 10.1093/toxsci/66.2.216